Synthesis and Study of 5–[(Phenylsulfonyl)Amino]–1,3,4– Thiadiazole–2–Sulfonamide as Potential Anti–Pertussis Drug Using Chromatography and Spectroscopy Techniques

Pertussis is a respiratory transmitted disease affecting approximately 23% of the worlds’ population. It is causes by Bordetella Pertussis [1-23]. The emergence of Multiple-Drug-Resistant (MDR) Pertussis has focused the attention of the scientific community thought the world on the urgent need for new anti–Pertussis drugs. In pursuit of this goal, our research efforts are directed toward the discovery of new chemical entities that are effective as anti–Pertussis drugs. During recent years, there have been intense investigations of different classes of 1,3,4-thiadiazole-2-sulfonamide compounds and derivatives such as 5-[(Phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide many of which are known to possess interesting pharmaceutical, biological, biochemical and biomedical properties suchlike anti–microbial, anti– Pertussis and anti–inflammatory activities. It should be noted that the purity of the synthesized compound was confirmed by High Performance Liquid Chromatography (HPLC) and also Thin–Layer Chromatography (TLC). Furthermore, the molecular and chemical structure of compound was characterized by 1HNMR, 13CNMR, Attenuated Total Reflectance Fourier Transform Infrared (ATR–FTIR), FT–Raman and HR Mass spectra.